The Novel Paradigm of Stroke Mechanism Research Based on Neurovascular Unit

Objective: Stroke is a kind of disease with high morbidity, high mortality and high disability rate. Since currently available drugs treating cerebral ischemia have many limitations, it is necessary to find a new treatment approaches. The emergence of neurovascular unit provides a new perspective for basic research of stroke. Methods: Summarize the literature of research data relevant on the neurovascular unit and ischemia stroke, looking for the new treatment targets in the neurovascular unit during stroke process.Results: Checking out dozens of foreign literature, it shows that neurovascular unit plays an important role during the pathological and healing process of stroke. Conclusion: Neurovascular unit associated with the concept of the stroke into an integrated tissue reaction among all the cells and matrix components involved in the process of tissue damage, not just neurons or blood vessels involved in the pathological reactions. The concept will brought new opportunities for the treatment of stroke.